[e-ISSN : 2277-2782]

Formulation and In vitro Evaluation of Floating Tablets of Lisinopril using Natural and Synthetic Polymers

International Journal of Novel Trends in Pharmaceutical Sciences,2017,7,5,164-177.
Published:October 2017
Type:Research Article
Authors:
Author(s) affiliations:

Sumayya Jabeen, K. Naga Raju, B. Deepika, T. Regupathi, K.N.V Rao, K. Rajeshwar Dutt

Department of Pharmaceutics, Nalanda college of Pharmacy, Charlapally, Nalgonda, Telangana, India.

Abstract:

In the present research work gastro retentive floating matrix Tablets of Lisinopril by using various polymers such as Sodium alginate, Guar gum and Carbopol 934 were developed. The formulation blend was subjected to various pre formulation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the F7 formulation with Carbopol 934 was retarded the drug release up to desired time period. The dissolution data of optimized formulation was subjected to release kinetics; from the release kinetics data it was evident that the formulation followed Zero order release kinetics.

Gastrointestinal motility pattern