[e-ISSN : 2277-2782]

Synthesis, Characterization and Biological Activity of 3- Indole Acetic Acid

International Journal of Novel Trends in Pharmaceutical Sciences,2015,5,1,21-24.
Published:February 2015
Type:Research Article
Authors:
Author(s) affiliations:

K. Trinagaraju1, A.V.G.S. Prasad1*, P. Venkateswara Rao1 and P.S.S. Prasad2

1Department of Chemistry, Nizam College (Autonomous), Hyderabad, Telangana, India

2Drug Control Administration, Hyderabad, Telangana, India.

Abstract:

On literature review, the studies on carboxylic acids reveal that their coordination chemistry has been studied extensively. However, in view of the absence of reports on the coordination chemistry of substituted acetic acid moieties the present investigation has been undertaken. In the present work, indole acetic acid (IAA) a base moiety was characterized by elemental analysis, Ultra Violet–Visible, FT-IR and 1H-NMR spectroscopy studies and the interaction of the base IAA with bivalent metal ions like cobalt (II), copper (II) and nickel (II) in non- aqueous media like ethanol was studied. The metal complexes of cobalt (II), copper (II) and nickel (II) ions with IAA are synthezised in solid state and their characterization was done by chemical analysis, electrical conductivity, elemental analysis and spectral measurement (UV-visible, FT-IR, and 1HNMR). Magnetic susceptibility values have also been measured for the complexes synthezised. The metal complexes have also been tested in vitro for their antibacterial and anti-fungal activity.

Antibacterial activity of 3-Indole acetic acid and metal complexes