Human beings most often come into contact with fungi in the organisms having natural habitats. Because many fungi live in the ground, gardeners are often at risk for fungal infections. The organisms can enter the body through bare feet, hands, skin, nail, or other exposed areas. Different kinds of fungi live in different geographic areas. Whatever form fungi take, they survive by breaking down organic matter. Only 300 out of the 1.5 million known species of fungi can cause disease in people. Mainly azole derivatives are used to treat fungal infection. Antifungal agents are available as various forms like creams, pessaries, shampoos, medicines to take by mouth, and injections. Nowadays newer antifungal agents also used to treat fungal disorders.