Buccal patches of Desloratidine were prepared by solvent evaporation method using HPMC 15 cps and xanthan gum which are the hydrophilic polymers in different ratios. The prepared patches were tested for physical parameters like Thickness, Folding endurance, Uniformity of weight, swelling index and Surface pH of patches and In-vitro drug release studies. All the physical parameters were fall within the limits. The drug content was uniform in all the formulated buccal patches of Desloratidine. The results indicate uniform distribution of drug within the patches. The release of Desloratidine from the buccal patch was sustained up to 6hrs. Among the five formulations, the F-V shows maximum drug release of 89.03% in 6 hrs. The optimized formulation follows zero order kinetics to release the drug from the patches.