[e-ISSN : 2277-2782]

Development of New Spectrophotometric Methods for the Determination of Perindopril in Pharmaceutical Dosage Forms

International Journal of Novel Trends in Pharmaceutical Sciences,2012,2,1,32-34.
Published:February 2012
Type:Research Article
Authors:
Author(s) affiliations:

CH.V. Suresh1,*, G. Vidya Sagar2

1Deparment of Biotechnology, Acharya Nagarjuna university, Nagarjuna Nagar, Guntur, Andhra Pradesh, India.

2Department of Pharmaceutical Analysis, Veerayatan Institute of Pharmacy, Kutch, Gujarat, India.

Abstract:

Three simple and sensitive Spectrophotometric methods have been developed for the determination of Perindopril (PDL) in pure and pharmaceutical dosage forms. Method A is based on the formation of Ion-assosiation complex of the drug with Bromothymol Blue (lmax: 415 nm). Method B is based on the formation of charge transfer complex of the drug with chloranilic acid (lmax: 580 nm). Method C is based on oxidation of the drug under alkaline conditions by oxidizing agents like potassium permanganate and subsequent formation of cherry red colored chromogen (lmax : 609 nm). These methods have been statistically evaluated and found to be precise and accurate.

Optical characteristics, Precision and Accuracy of the proposed methods