[e-ISSN : 2277-2782]

Evaluation of in vitro Antioxidant Activity of 1,2,3,4 -Tetrahydroquinazoline Derivatives

International Journal of Novel Trends in Pharmaceutical Sciences,2011,1,1,1-5.
Published:October 2011
Type:Research Article
Authors:
Author(s) affiliations:

B. Vijayakumar1*, C.P. Kumar1, G. Sivaprasad1, Kanjeri Nirosha1, Sureka Rokkam1 and E. Mohanambal2

1Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, R.V.S.Nagar, Chittoor, Andhra Pradesh, India.

2Department of Pharmaceutics, Sri Venkateswara College of Pharmacy, R.V.S. Nagar, Chittoor, Andhra Pradesh, India.

Abstract:

Quinazolines show a number of biological activities. The molecular manipulation of promising lead compound is still a major line of approach for the discovery of new drugs. Combination of two or more moieties into one is a common procedure of manipulation and this can probably result in the increase of biological activity and removal of untoward side effects. In this present work effort was made to synthesis twelve tetrahyroquinazoline derivatives by using different aldehydes. The synthesized compounds evaluated for physical characterization like, molecular weight, melting point, Rf value and solubility. The structure of the synthesized compounds was confirmed by spectral analysis like IR, NMR and Mass. The synthesized compounds were subjected for evaluation antioxidant activity. The compound 4a1 and 4a3 showed more promising antioxidant activity against reducing power assay, phosphomolybdate method. The tetrahydroquinazoline and its derivative have shown better antioxidant activity compared to the standards like BHA and ascorbic acid respectively.

Antioxidant activity DPPH radical scavenging Method